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KMID : 1149120220190020046
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Journal of the Korean Society for Psoriasis
2022 Volume.19 No. 2 p.46 ~ p.48
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A Case of Ixekizumab-induced Paradoxical Palmoplantar Pustulosis Successfully Treated with Guselkumab
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Lee Jin-Su
Kim Yeon-A
Won Sang-Hyeon
Bae Kyung-Nam
Lee Jung-Soo
Shin Ki-Hyuk
Kim Hoon-Soo
Ko Hyun-Chang
Kim Moon-Bum
Kim Byung-Soo
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Abstract
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Paradoxical reaction refers to the appearance or worsening of pathological responses during treatment with biologics. Pathological responses appear in pre-existing lesions or in other forms, and palmoplantar pustulosis (PPP) is one of the most common forms. Most biologics that cause paradoxical reactions are tumor necrosis factor (TNF) blockers. Recently, new biologics have been released, and paradoxical reactions by these biologics have also been reported. A 59-year-old woman with a 19-year history of plaque psoriasis started treatment with ixekizumab. After 4 months of treament PASI 100 was achieved and well controlled. However the patient presented progressive worsening of pustular lesions on the palms and soles. The patient was diagnosed as PPP on histopathological examination and improved after switching to guselkumab.
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KEYWORD
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Guselkumab, Ixekizumab, Palmoplantar pustulosis, Paradoxical reaction
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